Primary Sclerosing Cholangitis

Primary sclerosing cholangitis (PSC) is a chronic cholestatic disorder characterised by inflammation and fibrosis of intrahepatic and extrahepatic bile ducts, resulting in multifocal biliary strictures. The cause of primary sclerosing cholangitis remains unclear but hypotheses include genetic factors, lymphocyte recruitment and activation, portal bacteraemia and bile salt toxicity. Secondary sclerosing cholangitis includes conditions where infections, thrombosis, iatrogenic causes or trauma can give rise to similar clinical characteristics to PSC.

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